21
Monday
September 2020
6:35 AM IST
News Headlines
Burkina Faso striker Traore leaves Lyon for Aston Villa        AIFF to conduct three-day International Virtual Conference for coaches        Looking to play good brand of cricket to make this season a memorable one: KL Rahul        US stocks fall as market decline extends for third week        No decision to discontinue printing of Rs 2000 note: FinMin        Iran vows 'hit' on all involved in US killing of top general        Russia's Navalny says he's now more than 'technically alive'        Pak uses drone to weapons in J-K's Rajouri; 3 LeT terrorists arrested        Centre rejects study which claims India is world's largest emitter of anthropogenic sulphur dioxide        Garib Kalyan Rojgar Abhiyaan not implemented in Bengal as state did not provide any info: FM        Parliament's monsoon session likely to be curtailed, may end by mid-next week        Kerala reports 4,000 plus fresh COVID-19 cases for second day in row; Toll crosses 500        China flies 18 warplanes near Taiwan during US envoy''s visit        US bans WeChat, TikTok citing national security        IPL 2020: Dhoni''s CSK lock horns with Rohit led MI in opener        US Open champion Osaka out of French Open due to injury        NIA questions Ker Minister Jaleel for over 8 hours; No need for him to resign, says CM        Delhi riots: Police files charge sheet under UAPA against 15 for larger conspiracy        Serum Institute gets DGCA''s nod to resume testing of Covid vaccine again        Russia''s RDIF collaborates with Dr Reddy''s Laboratories for Sputnik V vaccine trials, distribution: CEO        
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International News
Carbohydrate that novel coronavirus uses to infect cells identified
 
Los Angeles: Scientists have identified a key carbohydrate molecule, called heparan sulphate, which the novel coronavirus uses to infect human cells, an advance that may provide a potential new approach for preventing and treating COVID-19. The molecule ACE2 sits like a doorknob on the outer surfaces of the cells that line the lungs, and researchers know that SARS-CoV-2 virus primarily uses it to enter these cells and establish respiratory infections. The study, published in the journal Cell, found that SARS-CoV-2 can''t grab onto ACE2 without heparan sulphate, which is also found on lung cell surfaces and acts as a co-receptor for viral entry. "ACE2 is only part of the story.

It isn''t the whole picture," said Jeffrey Esko, a professor at the University of California San Diego School of Medicine in the US. The team demonstrated two approaches that can reduce the ability of SARS-CoV-2 to infect human cells cultured in the lab by approximately 80 to 90 per cent. The first approach works by removing heparan sulphate with enzymes, and the second uses heparin as bait to lure and bind the coronavirus away from human cells, according to the researchers. Heparin, a form of heparan sulphate, is already a widely used medication to prevent and treat blood clots, suggesting that an approved drug might be repurposed to reduce virus infection, they said.

The team uncovered the exact part of the SARS-CoV-2 spike protein that interacts with heparin -- the receptor binding domain. The researchers found that when heparin is bound, the receptor binding domain opens up and increases binding to ACE2. The virus must bind both heparan sulphate on the cell surface and ACE2 in order to get inside human lung cells grown in a laboratory dish, they said. With this viral entry mechanism established, the researchers next set about trying to disrupt it. They found that enzymes that remove heparin sulphate from cell surfaces prevent SARS-CoV-2 from gaining entry into cells. Similarly, treatment with heparin also blocked infection, according to the researchers.

The heparin treatment worked as an anti-viral at doses currently given to patients, even when the researchers removed the anticoagulant region of the protein -- the part responsible for preventing blood clots, they said.


Iran vows 'hit' on all involved in US killing of top general
Russia's Navalny says he's now more than 'technically alive'
China flies 18 warplanes near Taiwan during US envoy''s visit
US bans WeChat, TikTok citing national security
Israel strikes Gaza after rocket fire during US ceremony
Seoul: N. Korea may conduct underwater-launched missile test
UN: Boat capsizes near Libya; 24 migrants presumed dead
Navalny posts hospital photo of himself; plans Russia return
Yoshihide Suga wins party vote for Japan prime minister
Russian opposition leader Navalny able to leave his bed
Vatican urges return to in-person Mass as soon as possible
Death toll from devastating US west coast wildfires approaching 30 - Reports
Blasts occur at Jordan munitions depot, no injuries reported
Foreign ministers of Russia, India, China meet in Moscow
Microsoft claims Russian hackers targeted Biden''s campaign advisory firm - Reports
UK PM plans law banning large gatherings as COVID-19 cases rise
'Biden's climate plan will give free pass to worst polluters like China, Russia, India'
Trump planning to withdraw more US troops from Iraq
Pak court sentences Christian man to death for committing blasphemy
Trump Wealth shrinks $600Mln in past year due to COVID-19 impact on real estate - Reports
ENTERTAINMENT NEWS
My whole life has been a miracle: Rajinikanth
 Mumbai: From starting out as a bus conductor to becoming one of the biggest stars of the: country,  
'Game of Thrones' star Indira Varma tests positive for coronavirus
Coronavirus: Release of Ranveer Singh-starrer '83' put on hold
'Joker' earns Joaquin Phoenix his maiden Oscar
KERALA NEWS
Take steps to attach properties of pvt financial institution; HC to govt
 Kochi: The Kerala High Court on Wednesday directed the state government to take steps to attach the
Kerala logs single-day highest spike of 3,830 COVID-19 cases
Jaleel has committed no wrong, says Kerala CM
"My hands are clean, not accepted any gift or money" Minister
NATIONAL NEWS
Pak uses drone to weapons in J-K's Rajouri; 3 LeT terrorists arrested
 Jammu, Sep 19 (PTI) Pakistan dropped weapons and some cash in Indian currency using a drone in Jammu
Centre rejects study which claims India is world's largest emitter of anthropogenic sulphur dioxide
Garib Kalyan Rojgar Abhiyaan not implemented in Bengal as state did not provide any info: FM
Delhi riots: Police files charge sheet under UAPA against 15 for larger conspiracy
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